32Ge Biological Activity of Organogermanium Compounds

E Lukevics, L Ignatovich - … Based Diagnostic Agents: The Use of …, 2005 - Wiley Online Library
… , hereafter Ge-132, for 24 weeks showed no toxic effects in mice. 27 … 85 Ge-132 can
antagonize the damage of neural behaviour … 87 The therapeutic effect of Ge-132 for experimental …

The role of germanium in diseases: exploring its important biological effects

X Luo, J Sun, D Kong, Y Lei, F Gong, T Zhang… - Journal of Translational …, 2023 - Springer
… identified several types of organogermanium compounds with significant antitumor effects
[52], … Ge-132 has been shown to have antitumor effects in mice and rats and has been used …

Bioorganic and medicinal organogermanium chemistry

T Nakamura, Y Shimada, K Sato - Organogermanium …, 2023 - Wiley Online Library
Ge-132 is an immunomodulatory agent [23–25] that activates … system for Ge-132, so the
Ge-132 derivative was screened in … , compounds with increased antitumor effects compared with …

Prevention of suppressed interferon gamma production in thermally injured mice by administration of a novel organogermanium compound, Ge-132

F Suzuki, RB Pollard - Journal of Interferon Research, 1984 - liebertpub.com
… Several immunomodulating effects have been demonstrated for … Ge-132 can exert an
antitumor effect in a tumor-bearing host."9"2'1 In addition to these biological activities, Ge-132 has …

[HTML][HTML] Advances in effect of germanium or germanium compounds on animals—a review

L Li, T Ruan, Y Lyu, B Wu - Journal of biosciences and medicines, 2017 - scirp.org
… is also an immune stimulant with broad spectrum of anti-tumor … toxic effects on the liver,
kidney and hematopoietic system [105] . Other organogermanium compounds such as Ge-132

Synthesis and biological evaluation of water-soluble organogermanium

S Choi, C Oh, J Han, J Park, JH Choi, NY Min… - European journal of …, 2010 - Elsevier
… and anticancer agent [7]. However, in spite of its beneficial … effects of Ge-132, it is generally
accepted that the biological mechanism of Ge-132 can be expressed as follows: (a) Ge-132

Therapeutic effects of organic germanium

S Goodman - Medical hypotheses, 1988 - Elsevier
… A phase I study with Ge-132 was performed with 23 healthy … Germanium compounds
have shown effective anticancer activity, … with an organogermanium compound, Ge-132. and …

Synthesis and synergetic anti-tumor activity evaluation of dihydroartemisinin-organogermanium (IV) compound

P Lu, S Yao, J Cai, P Yang - Bioorganic & Medicinal Chemistry Letters, 2014 - Elsevier
Ge-132, we synthesized a novel organogermanium compound that possessed better antitumor
… not only had much lower toxicity, but also possessed immunomodulatory activity, anti-…

Ability of sera from mice treated with Ge-132, an organic germanium compound, to inhibit experimental murine ascites tumours

F Suzuki, RR Brutkiewicz, RB Pollard - British journal of cancer, 1985 - nature.com
Effect of Ge-132 as an immunomodulator. In … of a novel organogermanium compound,
Ge-132. J. Interferon Res., 4, 223. … Antitumor activity of Ge-132, a new organogermanium

Potential of germanium-based compounds in coronavirus infection

V Narokha, I Nizhenkovska, O Kuznetsova - Acta Pharmaceutica, 2022 - hrcak.srce.hr
… of Ge-132 immunomodulatory and antioxidant effects via … Nakamura, Organogermanium
(Ge-132) suppresses activities … antitumor activity of carboxyethylgermanium sesquioxide (…